Early
Progesterone is rising steadily. The corpus luteum — left behind after ovulation — produces progesterone, raising body temperature and resting metabolism. Estrogen holds and then begins to decline. Warm, stable, and capable in a quieter register than ovulation.
Progesterone — rising
Estrogen — declining
Body temperature — elevated
Metabolism — higher
Mid
Progesterone is near or at its peak. It converts to allopregnanolone — a compound that binds to GABA receptors and produces genuine calm and a narrowing of social appetite. Metabolism runs 100–200 calories higher than baseline. The pull toward fewer people and more depth is directly hormonal.
Progesterone — peak
Allopregnanolone — high
Metabolism — elevated
Late
Progesterone begins to fall as the corpus luteum breaks down. Estrogen follows. This dual withdrawal directly reduces serotonin and dopamine — the biological cause of low mood, irritability, and heightened sensitivity. Amygdala reactivity increases by up to 30%, meaning emotional responses genuinely run larger than the situation warrants.
Progesterone — falling
Estrogen — falling
Serotonin — dropping
Amygdala reactivity — elevated